Characterizing the BCR repertoire during lymphocyte reduction and recovery mediated by cyclophosphamide and granulocyte-macrophage colony-stimulating factor

Jun Li,Yuehong Li,Suhong Sun,Liwen Yang,Long Ma,Bin Shi,Rui Ma,Xinsheng Yao

International Immunopharmacology（2021）

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摘要

•GM- CSF increases the number of white blood cells.•GM -CSF can partially restore BCR heavy chain CDR3 repertoire.•GM -CSF may lead to rearrangement, proliferation and activation of abnormal B cells.

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关键词

BCR CDR3 repertoire,CTX,GM -CSF,High throughput sequencing,Leukopenia

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