Liujunzi decoction exerts potent antitumor activity in oesophageal squamous cell carcinoma by inhibiting miR-34a/STAT3/IL-6R feedback loop, and modifies antitumor immunity.

Yicun Han,Xiuqi Fan, Liyan Fan,Yaosong Wu,Zhexu Zhou,Ge Wang,Lanwei Guo, Wendong Gao,Yulong Chen,Qilong Gao

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

LJZD exerts excellent antitumor effect by interfering with the miR-34a/STAT3/IL-6R feedback loop and augmenting antitumor immune responses. Which provides new insights into mechanisms for LJZD and sheds light on the multifaceted role of phytomedicine in cancer.

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关键词

Immunity,Liujunzi decoction,Oesophageal squamous cell carcinoma,Programmed death-1/ligand1,miR-34a/STAT3/IL-6R feedback loop

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