Cardiovascular Manifestations of Monkeypox Virus Outbreak: an Overview of the Reported Cases.

Background: Monkeypox (Mpox) is a zoonotic DNA virus related to the orthopoxvirus family that causes also smallpox infection. Objectives: In this paper, we aimed to study the cardiovascular manifestations of Mpox. Method: A literature databases search was conducted on 20th October 2022 and limited to 2022 (the new outbreak) to collect all the relevant papers that discussed cardiovascular manifestations in Mpox. Results: The literature included 6 cases of myocarditis, one case of pericarditis, one case of myopericarditis and one case of atrial fibrillation. Of total 6 cases with completed data, ECG results and troponin levels were abnormal in 5 cases while only three cases had abnormal ECHO and CMR results. In the four cases who undergone chest X-rays, only one patient had non-specific retro-cardiac opacities. All patients (9 cases) recovered well from their cardiovascular manifestations with no deaths and only 3 of them required ICU admission. Conclusion: With the limited reported cases, we recommend performing cardiovascular examinations-in particular ECG and troponin levels-in order to exclude cardiovascular insult in patients with suspected Mpox-cardiovascular involvement. However, in our series the infection was mild in most patients with no mortality. (c) 2023 Elsevier Inc. All rights reserved.