Testicular architecture of men with 46,XX testicular Disorders of Sex Development.

Mirkka Hiort,Julia Rohayem,Regine Knaf,Sandra Laurentino,Agnethe Berglund,Claus H Gravholt,Jörg Gromoll,Joachim Wistuba

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation（2023）

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摘要

Testicular architecture and marker expression of SCs and LCs in 46,XX TDSD men display unique pattern, which are discernable from chromosomal aneuploidies. Given the reduced Y chromosomal gene content in 46,XX TDSD, the supernumerary X chromosome effects may be decisive regarding the damage on testicular composition and endocrine function.

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