Plasma circulating tumor DNA profiling in patients with chemo-refractory germ cell tumors.

Shotaro Sakka,Shuya Kandori,Koji Kawai,Takahiro Kojima,Satoshi Nitta,Ichiro Chihara,Yoshiyuki Nagumo,Takashi Kawahara,Bryan J Mathis, Megumi Ishihara,Nobuo Shinohara,Takeshi Kishida,Osamu Ukimura,Kazuo Nishimura,Yasuyuki Kobayashi,Hiroyuki Nishiyama

International journal of urology : official journal of the Japanese Urological Association（2023）

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摘要

Analysis of plasma circulating tumor DNA could detect genetic alterations in patients with chemo-refractory GCT. Moreover, detectable circulating tumor DNA in plasma was associated with poor prognosis in those patients. These results suggest that liquid biopsy using analysis of plasma circulating tumor DNA may be clinically useful for germ cell tumor patients.

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chemotherapy resistance,germ cell tumor,liquid biopsy,next-generation sequencing,plasma circulating tumor DNA

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