OnabotulinumtoxinA effects on trigeminal nociceptors.

Ashley A Moore,Mariana Nelson, Christopher Wickware,Shinbe Choi,Gene Moon, Emma Xiong, Lily Orta,Amy Brideau-Andersen,Mitchell F Brin,Ron S Broide,Wolfgang Liedtke,Carlene Moore

Cephalalgia : an international journal of headache（2023）

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摘要

Our data deepen the understanding of the sensory mechanism of action of onabotulinumtoxinA and support the notion that, once endocytosed, the cytosolic light chain of onabotulinumtoxinA cleaves synaptosomal-associated protein-25 kDa to prevent soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated processes more generally in motor, autonomic, sensory neurons.

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关键词

Inflammatory soup,botulinum neurotoxin type A,chronic migraine,transient receptor potential ankyrin 1 (TRPA1),transient receptor potential vanilloid subtype 1 (TRPV1),trigeminal ganglion

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