Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans.
Liver international : official journal of the International Association for the Study of the Liver（2023）
摘要
In conclusion, OMVs induce inflammation, fibrosis and suppression of albumin production, affecting the pathogenesis of cirrhosis. We believe that our study paves the way for the future prevention and treatment of cirrhosis.
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关键词
C-type lectin domain family 4 member E,leaky gut,macrophage,neutrophil,single-cell transcriptome analysis
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