Overexpressed LAMC2 promotes trophoblast over-invasion through the PI3K/Akt/MMP2/9 pathway in placenta accreta spectrum.

Runfang Wang,Weifang Liu, Jing Zhao, Li Liu,Shengxian Li,Ya Duan,Yan Huo

The journal of obstetrics and gynaecology research（2023）

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摘要

Our study highlighted the involvement of LAMC2 in the pathogenesis of PAS by activating the PI3K/Akt/MMP2/9 signaling pathway to stimulate trophoblast over-invasion. These findings provide a new target for the diagnosis and disease stratification of PAS.

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关键词

LAMC2,MMP,PI3K/Akt,invasion,placenta accreta spectrum

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