Editorial: Advances and challenges in untargeted metabolomics.

Metabolomics is an emerging approach in the systems biology field. An untargeted strategy, which is 16 not driven by any preliminary assumption, aims to define changes in the whole metabolome, which 17 occur at the specific state in cells, tissues, or whole organism [Moco et al. 2023]. This allows to state 18 new hypotheses and may direct the research into a new and often unexpected course. Despite the 19 excellent advances that were made in the last decade, some improvements are still required at each 20 stage of the untargeted metabolomics workflow. 21The main aim of this Research Topic is to unveil novel techniques and tools in the field of untargeted 22 metabolomics, focusing on their applications.