Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.

Lingli Wang,Jan-Renier Moonen,Aiqin Cao,Sarasa Isobe,Caiyun G Li,Nancy F Tojais,Shalina Taylor,David P Marciano,Pin-I Chen,Mingxia Gu,Dan Li,Rebecca L Harper,Nesrine El-Bizri,Yu-Mee Kim,Kryn Stankunas,Marlene Rabinovitch

Circulation research（2023）

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摘要

Agents that neutralize the elevated ARRB2 resulting from loss of BMPR2 in PASMC could prevent or reverse the aberrant hypocontractile and hyperproliferative phenotype of these cells in PAH.

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关键词

beta-arrestin 2,bone morphogenetic protein receptors, type II,pulmonary arterial hypertension,smooth muscle cells,transgenic mice

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