Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release.

Michael P Greenwood,Mingkwan Greenwood,Soledad Bárez-López, Joe W Hawkins, Katherine Short, Danijela Tatovic,David Murphy

Molecular metabolism（2023）

引用 2|浏览5

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摘要

In summary, we show that GLP-1R signalling inhibits the vasopressin system. Our data advises that hydration status may influence the pharmacodynamics of GLP-1R agonists so should be considered in current therapeutic strategies.

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关键词

Glucagon like peptide 1,Hydration,Hypothalamus,Liraglutide,Oxytocin,Vasopressin

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