A Unified, Microwave-Assisted, Palladium-Catalyzed Regioselective Ortho-monohalogenation of 1-Alkyl/benzyl-3-Phenylquinoxalin-2(1H)-ones

A Unified, Microwave assisted, Pd-catalyzed regioselective ortho-monohalogenation of 3-phenylquinoxalin-2(1H)-one derivatives has been disclosed using readily available N-halosuccinimides (NXS). The nitrogen atom of quinoxalin-2(1H)-one facilitated as an effective directing group and helped in achieving regioselective mono halogenation at ortho-position of 3-phenyl ring of 3-phenylquinoxalin-2(1H)-ones. Under mild reaction condition, a wide diversity of mono halogenated products were obtained with wide substrate scope and high functional group tolerance in good yields. Post-functionalization of the synthesized molecules has been demonstrated.