Construction of PAMAM-based Nanocomplex Conjugated with Pt(IV)-complex and Lauric Acid Exerting Both Anti-tumor and Antibacterial Effects

Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer (CRC), however, the harmful Fusobacterium nucleatum (Fn) that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin, which reduces the anticancer efficiency. Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(IV)-complex and lauric acid (LA) to the dendritic carrier PAMAM (G=3). The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid (HA) on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting. The biocompatibility, anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated in vitro. The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility, high anti-colorectal cancer activity and high anti-Fn activity. This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.