Enhanced brain mitophagy slows systemic aging
NATURE AGING(2022)
摘要
Compromised clearance of dysfunctional mitochondria, through the process of mitophagy, has garnered attention as an essential contributor to aging and neurodegeneration. Schmid and colleagues 1 reveal that genetic enhancement of mitophagy via neuronal overexpression of BNIP3 alleviates brain aging and prolongs healthspan in fruit flies.
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关键词
Alzheimer's disease,Mitophagy,Life Sciences,general
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