A novel CDK8 inhibitor with poly-substituted pyridine core: Discovery and anti-inflammatory activity evaluation in vivo

Xing Chen,Yaoyao Yan,Xiu Cheng,Zhaoyan Zhang,Chuanbiao He,Dan Wu,Dahai Zhao,Xinhua Liu

Bioorganic Chemistry（2023）

引用 1|浏览10

暂无评分

摘要

•Novel CDK8 inhibitors were designed and synthesized.•The structure-based optimization and SAR study were fully carried out.•It augmented the abundance of IL-10 and showed potent effect against IBD.

查看译文

关键词

Interleukin 10,CDK8 inhibitor,Inflammatory bowel disease,Anti-inflammatory activity

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要