Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia.

Lourdes Figueroa,Natalia Kraeva,Carlo Manno,Carlos A Ibarra-Moreno,Eshwar R Tammineni,Sheila Riazi,Eduardo Rios

British journal of anaesthesia（2023）

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摘要

Enhanced sensitivity to depolarisation and to halothane appear to be the primary, mutually reinforcing and phenotype-defining defects of halothane-hypersensitive patients with malignant hyperthermia susceptibility.

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关键词

calcium signalling,excitation–contraction coupling,malignant hyperthermia,skeletal muscle,volatile anaesthetics

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