Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea.

Jeannette Rodriguez,Joan B Escobar,Emily C Cheung,Grant Kowalik,Rebekah Russo,Jhansi Dyavanapalli,Bridget R Alber, Grey Harral, Aman Gill, Makeda Melkie,Vivek Jain,Kathryn J Schunke,David Mendelowitz,Matthew W Kay

Hypertension (Dallas, Tex. : 1979)（2023）

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摘要

In animals already presenting with CIH-induced hypertension, chronic activation of hypothalamic oxytocin neurons blunted the progression of hypertension and conferred cardioprotection after an additional 4 weeks of CIH exposure. These results have significant clinical translation for the treatment of cardiovascular disease in patients with obstructive sleep apnea.

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关键词

blood pressure,hypertension,hypothalamus,oxytocin,parasympathetic nervous system,sleep apnea, obstructive,transcriptome

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