Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice.

Elisa Proietti,Renske W M Pauwels,Annemarie C de Vries,Elena Orecchini,Claudia Volpi,Ciriana Orabona,Maikel P Peppelenbosch,Gwenny M Fuhler,Giada Mondanelli

International journal of tryptophan research : IJTR（2023）

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摘要

This is the first study demonstrating immunomodulatory activity of IDO1 in a chronic mouse model of DSS-induced colitis. As its expression and catalytic activity correlate with the grade of mucosal inflammation and treatment response, IDO1 could represent a promising biomarker for disease severity and treatment monitoring in IBD.

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关键词

IBD,Indoleamine 2,3 dioxygenase-1,N-acetyl serotonin,Ustekinumab,Vedolizumab,colitis

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