Adherence, Safety and Satisfaction of a Cardio-Oncology Rehabilitation Program Framework Versus Community Exercise Training for Cancer Survivors: Findings from the CORE Trial

To assess safety, satisfaction, and overall adherence of a center-based cardiac rehabilitation (CBCR) program for cancer survivors at increased cardiovascular (CV) risk, compared to community-based exercise training (CBET). The CORE study was a single-center, prospective, randomized controlled trial enrolling cancer survivors exposed to cardiotoxic cancer treatment and/or with previous CV disease. Participants were randomized to an 8-week CBCR program or CBET, twice a week. Overall feasibility (consent, retention, and completion rates), intervention adherence (percentage of exercise sessions attended), and safety were assessed. Adverse events (AEs) were registered, and participants’ satisfaction was measured at the end of the study. Eighty out of 116 potentially eligible individuals were included; consent rate was 72.4