Copper-Catalyzed Diastereo- and Enantioselective Decarboxylative [3+2] Cyclization of Alkyne-Substituted Cyclic Carbamates with Azlactones: Access to gamma-Butyrolactams Bearing Two Vicinal Tetrasubstituted Carbon Stereocenters
Organic letters(2023)
摘要
A copper-catalyzed diastereo-and enantioselective decar-boxylative [3 + 2] cyclization reaction of alkyne-substituted cyclic carbamates with azlactones has been established. A range of optically pure gamma-butyrolactams bearing two vicinal tetrasubstituted carbon stereo-centers were obtained in high yields with good to excellent stereo-selectivities (up to 99% yield, 99:1 dr, and 99% ee). This is the first example of asymmetric synthesis gamma-butyrolactams containing sterically congested vicinal tetrasubstituted stereocenters via a decarboxylative cyclization pathway.
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