Levosimendan attenuates electrical alternans and prevents ventricular arrhythmia during therapeutic hypothermia in isolated rabbit hearts.

Yu-Shan Chien,Chi-Jen Weng,Shang-Ju Wu,Cheng-Hung Li,Jiunn-Cherng Lin,Jin-Long Huang,Shien-Fong Lin,Yenn-Jiang Lin,Yu-Cheng Hsieh,Shih-Ann Chen

Heart rhythm（2023）

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摘要

During TH, levosimendan could protect hearts against VA by shortening APD and decreasing SDA threshold. Enhancing ATP-sensitive K current with levosimendan might be a novel approach to preventing VA during TH.

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关键词

Action potential duration,Alternans,Hypothermia,Levosimendan,Optical mapping

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