Examining the Relationships Among Treatment, Pain, and Physical Function in Patients With Osteoarthritis: A Mediation-Modeling Approach.

Lucy Abraham,Robert H Dworkin,Dennis C Turk,John D Markman,David A Williams,Andrew G Bushmakin,Jerry A Hall,David C Semel,Joseph C Cappelleri,Ruoyong Yang

The Clinical journal of pain（2023）

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摘要

At least 75% of the treatment effect of tanezumab on physical functioning can be explained by the improvements in pain. However, tanezumab had an additional effect on physical functioning (~25%) that, was independent of improvements in pain. Such independent effects are of considerable interest and require further research to determine their mechanisms.

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mediation modeling,pain,physical function,direct effect,indirect effect

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