Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers of Alzheimer's Disease and Vascular Pathology.

Dror Shir,Michelle M Mielke,Ekaterina I Hofrenning,Timothy G Lesnick,David S Knopman,Ronald C Petersen,Clifford R Jack,Alicia Algeciras-Schimnich,Prashanthi Vemuri,Jonathan Graff-Radford

Journal of Alzheimer's disease : JAD（2023）

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摘要

The influence of vascular pathology in the general population on CSF (N) biomarkers is modest, with greater influence of infarcts than white-matter disruption. Neurodegeneration markers more closely correlated with tau than amyloid markers.

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关键词

Alzheimer’s disease,amyloid,cerebrospinal fluid,neurodegeneration,neurofilament light chain,neurogranin,total tau,white matter integrity

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