Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume.

Woo-Jin Lee,Keun-Hwa Jung,Han Song,Heesun Lee,Hyo Eun Park,Youngil Koh,Su-Yeon Choi,Kyung-Il Park

CNS neuroscience & therapeutics（2023）

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摘要

Clonal hematopoiesis with DNMT3A mutation is quantitatively associated with a lower volume of cerebral WMH, especially in the periventricular region. CHIP with DNMT3A mutation might have a protective role in the endothelial pathomechanism of WMH.

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关键词

DNMT3A ,clonal hematopoiesis of indeterminate potential,white matter hyperintensity

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