Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography.

Catherine G Fitzgerald Dickmann,Alexander F McDonald,Nhi Huynh,Angela Rigopoulos,Zhanqi Liu,Nancy Guo,Laura D Osellame,Michael A Gorman,Michael W Parker,Hui K Gan,Andrew M Scott,Uwe Ackermann,Ingrid J G Burvenich,Jonathan M White

Chemical communications (Cambridge, England)（2023）

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摘要

Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [F]BiPET-2, and its and preclinical evaluation in glioblastoma models.

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