New cellular imaging-based method to distinguish the SPG4 subtype of hereditary spastic paraplegia.

Francesca Sardina,Davide Valente,Gaia Fattorini,Ettore Cioffi,Gianmarco Dalla Zanna,Alessandra Tessa,Daniela Trisciuoglio,Silvia Soddu,Filippo M Santorelli,Carlo Casali,Cinzia Rinaldo

European journal of neurology（2023）

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摘要

These findings open the possibility of a rapid, non-invasive, inexpensive test useful to recognize SPG4-hereditary spastic paraplegia subtype and evaluate the effects of spastin-enhancing drug in non-neuronal cells.

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关键词

SPG4,biomarker,hereditary spastic paraplegia,microtubule

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