Usp25 Deficiency Promotes T Cell Dysfunction and Transplant Acceptance via Mitochondrial Dynamics

J. Li, J. Wang, P. Lan,Z. Chen

International Immunopharmacology（2023）

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摘要

•USP25 was associated with T cell activation in graft rejection.•USP25-deficiency alleviated heart allograft rejection and significantly prolonged allo-graft survival.•USP 25-deficiency mice showed delayed skin allograft rejection.•Usp25-/- T cell showed dysfunction and impaired cytotoxic ability.•USP25 interacts with ATP5a1 and affects mitochondrial related ATP synthesis.

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关键词

USP25, T cell dysfunction,Mitochondrial dynamics,ATP5a1, ATP5b

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