Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients

Masahiro Ohara,Kosei Hirata,Mark Hallett,Taiki Matsubayashi,Qingmeng Chen,Satoko Kina,Kaoru Shimano,Akihiro Hirakawa,Takanori Yokota,Takaaki Hattori

Parkinsonism & Related Disorders（2023）

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摘要

•Long-term levodopa can improve the sequence effect in Parkinson's disease patients.•The improvement in the sequence effect depends on the gait conditions.•The sequence effect may be exaggerated by asymmetrical stride length.•The sequence effect may be exaggerated by cognitive motor interference.

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关键词

Sequence effect,Parkinson's disease,Levodopa,Gait analysis

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