Poly(I:C) Exacerbates Airway Goblet Cell Hyperplasia and Lung Inflammation in HDM-Exposed Balb/C Mice by YAP/FOXM1 Pathway.

Mei-Ling Bu,Meng-Hui Li,Mei Feng,Jin-Rong Wang,Lifeng Sun

International archives of allergy and immunology（2023）

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摘要

Poly(I:C) promotes airway epithelial goblet cell hyperplasia, mucus hypersecretion, and airway hyperresponsiveness. It also upregulates the expression of inflammatory factors in lung tissue and BALF in asthmatic mice by the YAP/FOXM1 pathway, resulting in asthma attacks.

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关键词

Airway inflammation,Asthma,Goblet cell hyperplasia,Poly(I:C),YAP

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