Detection of Pretreatment Circulating Tumor DNA Predicts Recurrence after High-Dose Proton Beam Therapy for Early-Stage Non-Small Cell Lung Cancer.

Masaki Nakamura,Shun-Ichiro Kageyama,Hidenari Hirata, Taku Tochinai,Hidehiro Hojo,Atsushi Motegi,Akinori Kanai,Yutaka Suzuki,Katsuya Tsuchihara,Tetsuo Akimoto

International journal of radiation oncology, biology, physics（2023）

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摘要

These results suggest that pretreatment ctDNA detection can predict out-of-field recurrence in patients with cT1-2N0M0 nonsquamous NSCLC treated with high-dose proton beam therapy.

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关键词

MRD: minimal residual disease,NSCLC, liquid biopsy, ctDNA, proton, radiotherapy Abbreviations: ES-NSCLC: early-stage non-small cell lung cancer,OS: overall survival,PBT: proton beam therapy,PFS: progression-free survival,SBRT: stereotactic body radiotherapy,ctDNA: circulating tumor DNA

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