Molecular Magnetic Resonance Imaging of Aneurysmal Inflammation Using a Redox Active Iron Complex.

Robert M King,Matthew J Gounis, Eric J Schmidt,Anita Leporati,Eric M Gale,Alexei A Bogdanov

Investigative radiology（2023）

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摘要

Magnetic resonance imaging using Fe-PyC3A injection in dynamic or delayed acquisition modes was shown to generate a higher magnetic resonance signal enhancement in aneurysms that exhibit higher degree of inflammation. The results of our pilot experiments support further evaluation of MRI using Fe-PyC3A as a noninvasive marker of aneurysmal inflammation.

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关键词

magnetic resonance imaging, redox sensing, dynamic imaging, iron chelate, reactive oxygen species, aneurysm, animal model

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