A new prognostic model for predicting outcomes of patients with recurrent or metastatic nasopharyngeal carcinoma receiving subsequent line (≥2 lines) anti-programmed death-1 monotherapy

•Liver metastasis, ALB, LDH, MLR, and pre-treatment plasma EBV-DNA were independent prognostic indicators for ICI outcomes.•A nomogram using these 5 factors can estimate anti-PD-1-response in RM-NPC patients.•The nomogram performed well in a training and in a validation cohort.•The nomogram could provide new insights into anti-PD-1 monotherapy in RM-NPC.