Forkhead box L2 is a target of miR-133b and plays an important role in the pathogenesis of non-small cell lung cancer.

Juan Li, Lirong Gao,Anqi Wang,Huiwen Qian,Jianjie Zhu,Shundong Ji,Jun Chen,Zeyi Liu,Cheng Ji

Cancer medicine（2023）

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摘要

miR-133b downregulates FOXL2 by targeting the 3'-UTR of FOXL2, thereby inhibiting cell proliferation, EMT and metastasis induced by the TGF-β/Smad signaling pathway in NSCLC. FOXL2 may be a potential molecular target for treating NSCLC.

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关键词

TGF-β/Smad signaling,carcinoma, non-small-cell lung cancer (NSCLC),epithelial-mesenchymal transition (EMT),forkhead box protein L2 (FOXL2),miR-133b

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