Coenzyme Q₁₀ for Enhancing Physical Activity and Extending the Human Life Cycle

Background: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ(10) is the most common form of CoQ in humans. A deficiency of CoQ(10) occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ(10) biosynthesis and, thus, lead to CoQ(10) deficiency. Objectives: This article aims to evaluate the cumulative studies and insights on the topic of CoQ(10) functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle. Results: Although supplementation with CoQ(10) offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used. Conclusion: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ(10) in a range of health conditions and diseases.