Synthesis and Anti-Tuberculosis Activity of Hexahydro-Benzo[D][1,3]Thiazin-5(6H)-One/Hexahydro- Benzo[D][1,3]Thiazin-5-ylideneamino)-Methanethiols

An efficient methodology has been developed for the synthesis of novel and structurally diverse hexa-hydro-benzo[d][1,3]thiazin-5-ones/hexahydro-benzo[d][1,3]thiazin-5-ylideneamino)methanethiols. The reaction has been carried out under reflux for up to 12 h and progress was monitored by TLC technique. The simple reaction conditions, metal free synthesis and easy workup are the attractive features of the reported synthetic methodology. The diversity of products with multiple functionalities synthesized could provide them a better place in biological science for evaluation against several diseases/disorders. Screening of the synthetic molecules (IIIa-IIIk) identified two compounds (IIIe and IIIj) with good inhibitory activity against M. tuberculosis H37Rv (32.0 and 5.0 mu g/mL, respectively).