Comparison of integrin alpha(v)beta(3) expression with Ga-68-NODAGA-RGD PET/CT and glucose metabolism with F-18-FDG PET/CT in esophageal or gastroesophageal junction cancers
EUROPEAN JOURNAL OF HYBRID IMAGING(2023)
摘要
Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of Ga-68-NODAGA-RGD PET/CT with that of F-18-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.Methods Ten Ga-68-NODAGA-RGD and ten F-18-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 +/- 8.4 y, range 40-69 y). Maximum SUV (SUVmax) and metabolic tumor volumes (MTV) were calculated. The Mann-Whitney U test and Spearman correlation analysis (rho) were used.Results Ga-68-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. F-18-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUVmax of F-18-FDG was significantly higher than those of Ga-68-NODAGA-RGD (4.9 [3.7-11.3] vs. 3.2 [2.6-4.2] g/mL, p = 0.014). Only one participant showed a higher SUVmax in an osseous metastasis with Ga-68-NODAGA-RGD as compared to F-18-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between F-18-FDG and Ga-68-NODAGA-RGD PET parameters (rho = 0.56, p = 0.012 for SUVmax, rho = 0.78, p < 0.001 for lesion-to-background ratios and rho = 0.58, p = 0.024 for MTV). We observed that F-18-FDG uptake was homogenous inside all the confirmed primary sites (n = 9). In contrast, Ga-68-NODAGA-RGD PET showed more heterogenous uptake in 6 out of the 9 confirmed primary sites (67%), seen mostly in the periphery of the tumor in 5 out of the 9 confirmed primary sites (56%), and showed slight extensions into perilesional structures in 5 out of the 9 confirmed primary sites (56%).Conclusions In conclusion, Ga-68-NODAGA-RGD has lower potential in the detection of esophageal or esophagogastric junction malignancies compared to F-18-FDG. However, the results suggest that PET imaging of integrin alpha(v)beta(3) expression may provide complementary information and could aid in tumor diversity and delineation.
更多查看译文
关键词
Esophageal cancer,PET,F-18-FDG,Ga-68-NODAGA-RGD,Integrin alpha(v)beta(3),Angiogenesis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要