Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia.

Mariam Murtadha,Miso Park,Yinghui Zhu,Enrico Caserta,Ada Alice Dona,Mahmoud Singer,Hawa Vahed,Theophilus Tasndoh, Asaul Gonzalez, Kevin Ly,James F Sanchez,Arnab Chowdhury,Alex Pozhitkov,Lucy Ghoda,Ling Li,Bin Zhang,Amrita Krishnan,Guido Marcucci, John Williams,Flavia Pichiorri

biorxiv（2023）

引用 0|浏览26

暂无评分

摘要

This work represents a potential advancement in the treatment of AML, as it involves the release of IFN-γ by T cells to induce CD38 expression and thus sensitizing leukemia stem cells, which have been resistant to current treatment regimens, to CD38-directed T cell engagers.

查看译文

关键词

leukemia stem cells,ifnγ/cd38 regulation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要