Premature T cell aging in major depression: A double hit by the state of disease and cytomegalovirus infection.

MDD patients show several signs of a CMV independent "MDD specific" premature T cell aging, such as a CMV independent increase in CD4 T memory cells and a latent naïve CD4 T-cell reduction and a latent CD8 T-cell increase. However, these two latent T cell senescence abnormalities only become evident with CMV infection (double hit).