Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis.

Katharine E Stott, Ajisa Ahmadu,Cheusisime Kajanga,Melanie Moyo, Ebbie Gondwe, Wezzie Chimang'anga,Madalitso Chasweka,Jennifer Unsworth,Ana Jimenez-Valverde, Bhavana Jagota, Reya V Shah,David S Lawrence,David G Lalloo,Tom Harrison,Joseph N Jarvis,William Hope,Henry C Mwandumba

The Journal of antimicrobial chemotherapy（2023）

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摘要

This study revealed significant interindividual variability in flucytosine PK in plasma and CSF in patients with HIV-associated cryptococcal meningoencephalitis. The population PK model is a first critical step for revised flucytosine regimens that maximize fungal killing and minimize toxicity and the emergence of resistance.

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关键词

meningoencephalitis,flucytosine,csf penetration,pharmacokinetics,hiv-associated

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