Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis.

Zoe Quandt,Stephanie Kim,Javier Villanueva-Meyer,Catherine Coupe,Arabella Young,Jee Hye Kang,Jinoos Yazdany,Gabriela Schmajuk,Stephanie Rush,Elad Ziv,Ana Luisa Perdigoto,Kevan Herold,Melissa G Lechner,Maureen A Su,J Blake Tyrrell,Jeffrey Bluestone,Mark Anderson,Umesh Masharani

Journal of the Endocrine Society（2023）

引用 4|浏览37

暂无评分

摘要

The association of CPI-hypophysitis with HLA DQ0602 suggests a genetic risk for its development. The clinical phenotype of hypophysitis appears heterogenous, with differences in timing of onset, changes in thyroid function tests, MRI changes, and possibly sex related to CPI type. These factors may play an important role in our mechanistic understanding of CPI-hypophysitis.

查看译文

关键词

adrenal insufficiency,hypophysitis,immune checkpoint inhibitors,immune-related adverse events,immunotherapy,pan-hypopituitarism

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要