Immune repertoire and responses to neoadjuvant TCHP therapy in HER2-positive breast cancer.

Junyoung Shin, Baknoon Ham,Jeong-Han Seo,Sae Byul Lee,In Ah Park,Gyungyub Gong,Sung-Bae Kim,Hee Jin Lee

Therapeutic advances in medical oncology（2023）

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摘要

The role of the diversity, richness, and density of the TCR and BCR repertoires as predictive markers for TCHP response was not identified. Compositions of low-frequency clones could be candidates for predictive factors of TCHP response; however, validation studies and further research are necessary.

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关键词

HER2-positive breast cancer,TCHP response prediction,immune repertoire,neoadjuvant TCHP treatment

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