Canonical and non-canonical functions of STAT in germline stem cell maintenance.

Yalan Xing,Kimberly Larson,Jinghong Li,Willis X Li

Developmental dynamics : an official publication of the American Association of Anatomists（2023）

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摘要

These results suggest that persistent JAK/STAT activation by niche signals leads to the accumulation of HP1 and uSTAT in GSCs, which promote heterochromatin formation important for maintaining GSC identity. Thus, the maintenance of Drosophila GSCs requires both canonical and non-canonical STAT functions within GSCs for heterochromatin regulation.

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关键词

Drosophila,germline stem cell,heterochromatin,non-canonical STAT

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