AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease.

Cailin Wang,Yanmin Chang,Jiahui Zhu,Yanqing Wu,Xingjun Jiang,Siyi Zheng,Gang Li,Rong Ma

Experimental neurology（2023）

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摘要

Our results demonstrated that AdipoRon treatment could significantly mitigate tau pathology, improve synaptic damage, and restore mitochondrial dynamics via the AMPK-related pathway, which provides a novel potential therapeutic approach to retard the progression of AD and other tauopathies diseases.

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关键词

AMPK pathway,AdipoRon,Alzheimer's disease,Mitochondrial dynamics,Tau pathology

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