Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma.

Alex Frias,Luca Di Leo,Asier Antoranz,Loulieta Nazerai,Marco Carretta,Valérie Bodemeyer,Chiara Pagliuca,Christina Dahl,Giuseppina Claps, Giulio Eugenio Mandelli,Madhavi Dipak Andhari,Maria Pires Pacheco,Thomas Sauter,Caroline Robert,Per Guldberg,Daniel Hargbøl Madsen,Francesco Cecconi,Francesca Maria Bosisio,Daniela De Zio

Journal for immunotherapy of cancer（2023）

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摘要

This study shows that loss of Ambra1 affects the TIME and the antitumor immune response in melanoma, highlighting new functions of Ambra1 in the regulation of melanoma biology.

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关键词

immunotherapy,melanoma,tumor microenvironment

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