Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resistant S. aureus

Neeraj Kumar Verma,Rikeshwer Prasad Dewangan,Munesh Kumar Harioudh,Jimut Kanti Ghosh

Bioorganic chemistry（2023）

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摘要

•L9βl-TL showed higher proteolytic stability, therapeutic index and activity against MRSA biofilm than Temporin-L (TL).•Though unordered in bacterial membrane-mimetic lipid vesicles, L9βl-TL depolarized these vesicles and live MRSA.•The results show the design of a TL-analogue with higher therapeutic potential by impairing its secondary structure.

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关键词

Antimicrobial peptide,MRSA biofilm,Methicillin resistant S. aureus,Temporin L,β-leucine

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