Prognostic utility of albumin-bilirubin grade in Japanese patients with primary biliary cholangitis.

Yuki Yamashita,Takeji Umemura,Takefumi Kimura,Satoru Joshita,Junko Hirohara,Toshiaki Nakano,Atsumasa Komori,Atsushi Tanaka

JHEP reports : innovation in hepatology（2023）

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摘要

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. This study examined the ability of albumin-bilirubin (ALBI) score/grade to estimate histological findings and disease progression in PBC by means of a large-scale nationwide cohort in Japan. ALBI score/grade were significantly associated with Scheuer's classification stage. Baseline ALBI grade measurements may be a simple non-invasive predictor of prognosis in PBC.

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关键词

ALBI, albumin-bilirubin,ALP, alkaline phosphatase,AMA, anti-mitochondrial autoantibody,AUC, area under the ROC curve,BZF, bezafibrate,HR, hazard ratio,LSM, liver stiffness measurement,LT, liver transplantation,M2BPGi, Mac-2-binding protein glycosylation isomer,PBC, primary biliary cholangitis,Prognosis,ROC, receiver-operating characteristic,Transplantation,UDCA, ursodeoxycholic acid,ULN, upper limit of normal,Ursodeoxycholic acid,pc, corrected p

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