RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.

Bethan L Clifford,Kelsey E Jarrett,Joan Cheng,Angela Cheng,Marcus Seldin,Pauline Morand,Richard Lee,Mary Chen,Angel Baldan,Thomas Q de Aguiar Vallim,Elizabeth J Tarling

Circulation research（2023）

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摘要

Our studies identify RNF130 as a novel posttranslational regulator of LDL-C levels via modulation of LDLR availability, thus providing important insight into the complex regulation of hepatic LDLR protein levels.

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关键词

cardiovascular diseases,endocytosis,lipids,lipoproteins,ubiquitin

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