Fit-Seq2.0: an Improved Software for High-Throughput Fitness Measurements Using Pooled Competition Assays.
Journal of molecular evolution(2023)
摘要
The fitness of a genotype is defined as its lifetime reproductive success, with fitness itself being a composite trait likely dependent on many underlying phenotypes. Measuring fitness is important for understanding how alteration of different cellular components affects a cell's ability to reproduce. Here, we describe an improved approach, implemented in Python, for estimating fitness in high throughput via pooled competition assays.
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关键词
Barcode,Fitness,Pooled growth,High-throughput phenotyping
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