Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure.

Babak J Orandi,M Chandler McLeod,Paul A MacLennan,William M Lee,Robert J Fontana,Constantine J Karvellas,Brendan M McGuire,Cora E Lewis,Norah M Terrault,Jayme E Locke

JAMA（2023）

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摘要

The FDA mandate limiting acetaminophen dosage to 325 mg/tablet in prescription acetaminophen and opioid products was associated with a statistically significant decrease in the yearly rate of hospitalizations and proportion per year of ALF cases involving acetaminophen and opioid toxicity.

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acetaminophen,prescription combination opioid products,paracetamol,fda mandate,acute liver failure

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