Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site

Shruti Choudhary,Krishna Kaku,Andrew J Robles,Ernest Hamel,Susan L Mooberry,Aleem Gangjee

Bioorganic & Medicinal Chemistry（2023）

引用 3|浏览6

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摘要

Simple Monocyclic Pyrimidine Analogs as Microtubule Targeting Agents Binding to the Colchicine Site. Structural simplification of pyrrolo[2,3–d]pyrimidine scaffold led to monomeric pyrimidine derivatives resulting in potent microtubule targeting agents (MTAs) as microtubule depolymerizer.

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关键词

Pyrimidines,Microtubule targeting agents,Colchicine site agents,Cytotoxins

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